Dr. Ghosh is an Assistant Professor in the Department of Chemistry and Biochemistry. He is focused on bridging the gap between spectroscopy and imaging, and exploring chemical contrast in biomedical imaging through spectral signatures of molecular assemblies. Seeing is believing, and Dr. Ghosh spends most of his time figuring out how to ‘see’ the chemistry of tissues and biomolecular aggregates. Current research in Dr. Ghosh’s lab (http://irislab.ua.edu) is funded through NSF and NIH R35 MIRA awards.
- Label Free Infrared Spectroscopic Imaging Reveals Heterogeneity of Beta Sheet Aggregates in Alzheimer’s Disease. M.P. Confer, B.M. Holcombe, A.G. Foes, J.M. Holmquist, S. Walker, S. Deb, A. Ghosh, J Phys Chem Lett. 12: 9662–9671, 2021.
- Structurally Distinct Polymorphs of Tau Aggregates Revealed by Nanoscale Infrared Spectroscopy, S. Banerjee, A. Ghosh, bioRxiv 2021.08.12.456130.
- Relating Post‐yield Mechanical Behavior in Polyethylenes to Spatially Varying Molecular Deformation Using Infrared Spectroscopic Imaging: Homopolymers, P. Mukherjee, A. Ghosh, N. Spegazzini, M.J. Lamborn, M.M. Monwar, P.J. DesLauriers, R. Bhargava, Macromolecules, 51 : 3836–3844, 2018.
- Mapping Solvation Environments in Porous Metal Organic Frameworks with Infrared Chemical Imaging. A. Ghosh, P. Mukherjee, S. Deb, R. Bhargava, J Phys Chem Lett. 8: 5325‐5330, 2017.
- Watching Proteins Wiggle: Mapping Structures with Two‐Dimensional Infrared Spectroscopy. A. Ghosh, J.S. Ostrander, M.T. Zanni. Chemical Reviews, 117: 10726–10759, 2017
The central premise of Dr. Ghosh’s research is to employ infrared spectroscopy to provide chemical contrast in optical and atomic force microscopy. Research in Dr. Ghosh’s group seeks to extend the unique capabilities of infrared spectroscopy towards molecular imaging and push the boundaries of existing technology through development and application of infrared microscopies towards problems of major societal importance, such as characterization of amyloid aggregates in neurodegenerative diseases like Alzheimer’s disease.